Phenol derivative

US7439397B2 · kind B2 · utility

Assignee

• PFIZER INC. · US

Inventors

• Ivan Richards · Kalamazoo, US
• Sue Cammarata · Portage, US
• Craig D. Wegner · New Milford, US
• Michael Hawley · Davis, US
• Mark P. Warchol · Kalamazoo, US
• Mark Kontny · Libertyville, US
• Walter Morozowich · Kalamazoo, US
• Karen Kolbasa · Manistique, US
• Malcolm W. Moon · Kalamazoo, US
• Dominique Bonafoux · Saint Louis, US
• Sergey Gregory Wolfson · Chesterfield, US
• Patrick J. Lennon · Webster Groves, US

Key dates

• Filing date: Mar 8, 2005
• Grant date: Oct 21, 2008
• Expiry date: Jun 18, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C237/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The compound 2-[(1R)-3-(diisopropylamino)-1-phenylpropyl]-4-(trifluoromethyl) phenol may be used to prepare the compound (3R)-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-N,N-diisopropyl-N-methyl-3-phenylpropan-1-aminium bromide by reaction with methyl bromide.