Polymer conjugates of mutated neublastin

US7442370B2 · kind B2 · utility

Assignee

• BIOGEN IDEC MA INC. · US

Inventors

• Dinah Wen-Yee Sah · Boston, US
• R. Blake Pepinsky · Arlington, US
• Paula Ann Boriack-Sjodin · Lexington, US
• Stephan S. Miller · Arlington, US
• Anthony Rossomando · Grafton, US
• Laura Silvian · Newton, US

Key dates

• Filing date: Jan 31, 2003
• Grant date: Oct 28, 2008
• Expiry date: Dec 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A dimer comprising a mutated neublastin polypeptide coupled to a polymer is disclosed. Such dimers exhibit prolonged bioavailability and, in preferred embodiments, prolonged biological activity relative to wild-type forms of neublastin.