Method for detecting the expression of an envelope protein of a human endogenous retrovirus and uses of a gene coding for said protein
US7442550B1 · kind B1 · utility
3Cited by
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13Claims
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Key dates
| Filing date | Sep 1, 2000 |
| Grant date | Oct 28, 2008 |
| Priority date | — |
| Expiry date | Sep 1, 2020 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2740/10022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for detecting the expression of a polypeptide in cells and for detecting the interaction between a polypeptide and cells, ex vivo or in vitro, wherein the polypeptide is selected from the group consisting of: a peptide comprising the cyt domain of the envelope protein of the human endogenous retrovirus, HERV-W; a peptide comprising amino acids 448-538 of SEQ ID NO: 1; and a peptide comprising a sequence having, for any series of 20 amino acids, at least 80% identity with amino acids 448-538 of SEQ ID NO: 1. Detection is established by the fusogenic power of the polypeptide, which is demonstrated by syncytia formation.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.