Long-acting hormone and growth factor compositions and uses thereof

US7442684B2 · kind B2 · utility

Assignee

• The Trustees of Columbia University in the City of New York · US

Inventors

• Joyce Lustbader · Tenafly, US
• Leslie Lobel · Omer, IL

Key dates

• Filing date: Jan 31, 2003
• Grant date: Oct 28, 2008
• Expiry date: Jul 31, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P5/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides VEGF-FSH compounds having increased serum half-lives relative to either native VEGF or FSH, in which both VEGF and FSH are biologically active. This invention also provides related compositions and methods for increasing fertility, egg production and spermatogenesis in a subject, as well as methods for increasing vascularization in a tissue, particularly in ovarian tissue.