Composition and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis and abnormal cell proliferation

US7442688B2 · kind B2 · utility

Assignee

• Baylor College of Medicine · US

Inventors

• Huda Y. Zoghbi · Houston, US
• Hugo Bellen · Houston, US
• Nessan Bermingham · London, GB
• Bassem Hassan · Houston, US
• Nissim Ben-arie · Mevaseret Tsiyon, IL

Key dates

• Filing date: Jun 3, 2004
• Grant date: Oct 28, 2008
• Expiry date: Jul 31, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q2600/158
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compositions and methods are disclosed for the therapeutic use of an atonal-associated nucleic acid or amino acid sequence. Also, an animal heterozygous for an atonal-associated gene inactivation is also disclosed having at least one atonal-associated nucleic acid sequence replaced by insertion of a heterologous nucleic acid sequence used to detect expression driven by an atonal-associated promoter sequence, wherein the inactivation of the atonal-associated nucleic acid sequence prevents expression of the atonal-associated gene.