Autoinducer molecules and uses therefor

US7442798B2 · kind B2 · utility

Assignees

• University of Iowa Research Foundation · US
• University of Rochester · US
• East Carolina University · US

Inventors

• Everett C. Pesci · Greenville, US
• Barbara H. Iglewski · Fairport, US
• Jared Milbank · Auckland, NZ
• James Pearson · Cambridge, US
• Andrew S. Kende · Pittsford, US
• Everett P. Greenberg · Iowa City, US

Key dates

• Filing date: May 11, 2004
• Grant date: Oct 28, 2008
• Expiry date: May 30, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Q1/045
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Novel bacterial quinolone signal molecules and, more particularly, pseudomonas quinolone signal (“PQS”) molecules, e.g., 2-heptyl-3-hydroxy-4-quinolone, and analogs and derivatives thereof are described. Therapeutic compositions containing the molecules, and therapeutic methods, methods of for regulating gene expression, methods for identifying modulators of the autoinducer molecules, and methods of modulating quorum sensing signaling in bacteria using the compounds of the invention are also described.