Process for the preparation of furopyrroles
US7442804B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 28, 2004 |
| Grant date | Oct 28, 2008 |
| Priority date | — |
| Expiry date | Oct 29, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present invention relates to a process for the preparation of furopyrroles of general formula (I), comprising (a) heating a compound of the formula (II) under microwave irradiation optionally in the presence of an inert solvent, wherein A1 and A2 are C1-C18alkyl, C2-C18alkenyl, C2-C18alkynyl, C5-C8cycloalkyl, C5-C8cycloalkenyl, aryl or heteroaryl, A3 is hydrogen, C1-C18alkyl, cyanomethyl, Ar3, —CR30R31—(CH2)m—Ar3 or Y—R32, wherein R30 and R31 independently of each other stand for hydrogen or C1-C4alkyl, or phenyl which can be substitute up to three times with C1-C4alkyl, Ar3 stands for aryl, C5-C8 cloalkyl, C5-C8cycloalkenyl or heteroaryl, which can be substituted one to three times with C1-C8alkyl, C1-C8alkoxy, halogen or phenyl, which can be substituted with C1-C8alkyl or C1-C8alkoxy one to three times, and m stands for 0, 1, 2, 3 or 4, R is C1-C18alkyl, in particular C1-C4alkyl, aryl, in particular phenyl, or aralkyl, in particular benzyl, which can be substituted one to three times with C1-C8alkyl, C1-C8alkoxy, or halogen, Y is —C(O)—, —C(O)O—, —C(O)NH—, —SO2NH— or —SO2— and R32 is C1-C18alkyl, Ar3, or aralkyl. The furopyrroles of the general formula (I) can be can be obtai…
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.