Antidiabetic bicyclic compounds

US7442808B2 · kind B2 · utility

Assignee

• MERCK & CO., INC. · US

Inventors

• Min Ge · Nanjing, CN
• Jiafang He
• Fiona Wai Yu Lau · Edgewater, US
• Gui-Bai Liang · Scotch Plains, US
• Songnian Lin · Sparta, US
• Weiguo Liu · San Leandro, US
• Shawn P. Walsh · Bound Brook, US
• Lihu Yang · Edison, US

Key dates

• Filing date: May 11, 2007
• Grant date: Oct 28, 2008
• Expiry date: May 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/08
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Tricyclic compounds containing a cyclopropyl carboxylic acid or carboxylic acid derivative (e.g. amide) fused to a bicyclic ring, including pharmaceutically acceptable salts and prodrugs thereof, are agonists of G-protein coupled receptor 40 (GPR40) and are useful as therapeutic compounds, particularly in the treatment of Type 2 diabetes mellitus, and of conditions that are often associated with this disease, including obesity and lipid disorders, such as mixed or diabetic dyslipidemia, hyperlipidemia, hypercholesterolemia, and hypertriglyceridemia.