Sequence variants of multi-drug resistance genes, MDR1 and MRP1, and methods for assessment of drug penetration and disposition
US7445897B2 · kind B2 · utility
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6Claims
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Key dates
| Filing date | Jan 26, 2005 |
| Grant date | Nov 4, 2008 |
| Priority date | — |
| Expiry date | May 15, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/158
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided are compositions relating to novel MDR1 polymorphisms, including nucleic acids, polypeptides, and recombinant cells, as well as methods for detection of MDR1 polymorphisms in biological samples and elucidation of the influence of MDR1 polymorphisms on MDR1 protein function. Also provided are a rat MRP1 cDNA and protein, stable cell lines expressing the rat MRP1 protein, and methods of assessing drug penetration or disposition in a cell line expressing a recombinant mammalian MRP1 or MDR1 protein, or a homolog thereof.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.