Method of nucleic acid typing for selecting registered donors for cross-matching to transfusion recipients
US7449295B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 24, 2005 |
| Grant date | Nov 11, 2008 |
| Priority date | — |
| Expiry date | Sep 10, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2600/16
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes—and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility. The genotypes can be matched based on the weighted clinical significance of a genotypic difference between donor and recipient, such that certain mismatches are more acceptable than others.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.