Identification of biomarkers for liver toxicity
US7452678B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 22, 2004 |
| Grant date | Nov 18, 2008 |
| Priority date | — |
| Expiry date | Sep 21, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/576
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to biomarker polypeptides, polynucleotides, and antibodies that have utility in predicting in vitro and/or in vivo hepatotoxicity of various drugs, compounds, or other therapeutic agents (i.e., test substances). Also related are screens, kits, microarrays, and cell culture systems that employ the polypeptides, polynucleotides, and/or antibodies of the invention. The reagents and methods of the invention are useful for predicting hepatotoxic effects resulting from treatment with one or more test substances, and can be utilized before, after, or concurrently with pre-clinical, clinical, and/or post-clinical testing. In this way, the reagents and methods of the invention can be used to identify test substances or combinations of test substances that cause hepatic injury, including idiosyncratic hepatotoxicity, and thereby prevent medical complications (e.g., liver failure) resulting from such injury.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.