Zinc-free and low-zinc insulin preparations having improved stability
US7452860B2 · kind B2 · utility
4Cited by
62References
3Claims
0Family size
Assignee
Inventor
Key dates
| Filing date | Mar 8, 2007 |
| Grant date | Nov 18, 2008 |
| Priority date | — |
| Expiry date | Mar 8, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P31/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to a formulation comprising a polypeptide selected from at least one of insulin, an insulin metabolite, an insulin analog, and an insulin derivative; at least one surfactant; optionally at least one preservative; and optionally at least one of an isotonicizing agent, a buffer or an excipient, wherein the formulation is free from or low in zinc. The invention also relates to the production of such insulin preparations and their use as pharmaceutical formulations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.