Use of substituted 2-(diaza-bicyclo-alkyl)-pyrimidone derivatives for the treatment of neurodegenerative diseases
US7452897B2 · kind B2 · utility
0Cited by
0References
8Claims
0Family size
Assignees
Inventors
Key dates
| Filing date | Mar 29, 2007 |
| Grant date | Nov 18, 2008 |
| Priority date | — |
| Expiry date | Mar 29, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D487/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to therapeutic uses of a 2-(diaza-bicyclo-alkyl)-pyrimidone derivative represented by formula (I):Wherein R1, R2, R3, R4 and n are as defined herein. Specifically, the compounds of formula (I) are used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3β, such as Alzheimer's disease. The invention relates also to intermediates for the preparation of compound of formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.