Alkyne compounds with MCH antagonistic activity and medicaments comprising these compounds

US7452911B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Dirk Stenkamp · Biberach, DE
• Stephan Georg Mueller · Warthausen, DE
• Gerald Juergen Roth · Biberach, DE
• Thorsten Lehmann-Lintz · Ochsenhausen, DE
• Klaus Rudolf · Warthausen, DE
• Philip Lustenberger · Warthausen, DE
• Kirsten Arndt · Biberach, DE
• Ralf Lotz · Schemmerhofen, DE
• Martin Lenter · Ulm, DE

Key dates

• Filing date: Oct 30, 2003
• Grant date: Nov 18, 2008
• Expiry date: Feb 6, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D495/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to alkyne compounds of general formula Iwherein the groups and residues A, B, W, X, Y, Z, R1 and R2 have the meanings given in claim 1. The invention further relates to pharmaceutical compositions containing at least one alkyne according to the invention. In view of their MCH-receptor antagonistic activity the pharmaceutical compositions according to the invention are suitable for the treatment of metabolic disorders and/or eating disorders, particularly obesity, bulimia, anorexia, hyperphagia and diabetes.