Compositions and methods for modifying toxic effects of proteinaceous compounds

US7452971B2 · kind B2 · utility

Assignee

• The Board of Regents of the University of Texas System · US

Inventors

• Ellen S. Vitetta · Dallas, US
• Victor F. Ghetie · Dallas, US
• Joan E. Smallshaw · Dallas, US
• Roxana G. Baluna · Richardson, US

Key dates

• Filing date: Oct 31, 2005
• Grant date: Nov 18, 2008
• Expiry date: Nov 5, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides methods to produce immunotoxins (ITs) and cytokines with a reduced ability to promote vascular leak syndrome (VLS). The invention also provides ITs and cytokines which have been mutated to lack amino acid sequences which induce VLS.