Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
US7452994B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 14, 2006 |
| Grant date | Nov 18, 2008 |
| Priority date | — |
| Expiry date | Dec 17, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.