Cycloalkyl substituted polyamines for cancer therapy and methods of synthesis therefor

US7453011B2 · kind B2 · utility

Assignee

• Progen Pharmaceuticals Limited · AU

Inventors

• Benjamin Frydman · Madison, US
• Andrei V. Blokhin · Fitchburg, US
• Aparajita Sarkar · Madison, US
• Hirak S. Basu · Madison, US
• Venodhar K. Reddy · Madison, US
• Laurence J. Marton · Madison, US
• Yu Wang · San Jose, US
• Aldonia Valasinas · Madison, US

Key dates

• Filing date: Jun 4, 2007
• Grant date: Nov 18, 2008
• Expiry date: Jun 4, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Conformationally restricted polyamine compounds useful in treatment of cancer and other diseases marked by abnormal cell proliferation are disclosed. Improved methods of synthesizing such compounds are also disclosed. In one method of the invention, a carbene-bearing or carbene equivalent-bearing compound is reacted with the double bond of an alkene compound to form a cyclopropyl ring as the first step in the synthesis.