Patent · US Expired

Modified virus comprising one or more non-native polypeptides

US7456008B2 · kind B2 · utility

8Cited by

2References

29Claims

0Family size

Assignee

Got-A-Gene AB · SE

Inventors

Leif Lindholm · Handen, SE
Anna Karin Nord · Stockholm, SE
Pierre Boulanger · Montpellier, FR

Key dates

Filing date	Jul 19, 2001
Grant date	Nov 25, 2008
Priority date	—
Expiry date	Jul 19, 2021

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2810/859
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

A modified virus including one or more non-native polypeptides, and the use of such viruses in therapy, particularly in the treatment of tumours or other cancerous cells are disclosed. The polypeptides includes one or more framework moieties each containing one or more binding moieties, and is capable of being expressed in the cytoplasm and nucleus of a mammalian host cell in a conformation which is maintained in the absence of a ligand for the binding moieties. The conformation allows the binding moieties subsequently to bind with the ligand, and the polypeptide is capable of transport through the nuclear membrane, wherein the modified virus has an altered tropism conferred by the binding moieties.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.