Pyridinium cationic lipids as gene transfer agents

US7456197B2 · kind B2 · utility

Assignee

• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• Alexandru T. Balaban · Galveston, US
• William A. Seitz · Dickinson, US
• Marc A. C. Ilies · Philadelphia, US
• Edward Bradbridge Thompson · Galveston, US
• Robert E. Garfield · Goodyear, US
• Betty H. Johnson · Beaumont, US
• Aaron Miller · Galveston, US
• Melissa J. Wentz · Pearland, US

Key dates

• Filing date: Jul 1, 2004
• Grant date: Nov 25, 2008
• Expiry date: May 4, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/87
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Pyridinium cationic lipids useful as non-viral gene delivery agents are disclosed. The agents are prepared by reaction of pyrylium salts with primary amines. Also disclosed are methods of trasfectind cells using the pyridinium cationic lipids as gene transfer agents.