Chromene-containing compounds with anti-tubulin and vascular targeting activity
US7456214B2 · kind B2 · utility
1Cited by
15References
20Claims
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Key dates
| Filing date | May 21, 2004 |
| Grant date | Nov 25, 2008 |
| Priority date | — |
| Expiry date | Jan 30, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Chrome compounds have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds as well as related derivatives are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.