Nogo receptor homologs that decrease inhibition of axonal elongation
US7456255B2 · kind B2 · utility
3Cited by
7References
16Claims
0Family size
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Key dates
| Filing date | Oct 6, 2006 |
| Grant date | Nov 25, 2008 |
| Priority date | — |
| Expiry date | Oct 6, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/00
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates generally to genes that encode proteins that inhibit axonal growth. The invention relates specifically to genes encoding NgR protein homologs in humans and mice. The invention also includes compositions and methods for modulating the expression and activity of Nogo and the NgR proteins. Specifically, the invention includes peptides, proteins and antibodies that block Nogo-mediated inhibition of axonal extension. The compositions and methods of the invention are useful in the treatment of cranial or cerebral trauma, spinal cord injury, stroke or a demyelinating disease.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.