Fusion proteins of interferon alpha muteins with improved properties
US7456257B2 · kind B2 · utility
17Cited by
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1Claims
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Key dates
| Filing date | Feb 18, 2004 |
| Grant date | Nov 25, 2008 |
| Priority date | — |
| Expiry date | Feb 18, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns human interferon alpha and in particular modified forms of interferon alpha 2 with improved properties. The improved proteins contain amino acid substitutions at specific positions that confer increased relative activity in biological assays. The invention provides also modified interferon alpha with improved biological activity concomitant with reduced immunogenic potential in the protein. The improved proteins are intended for therapeutic use in the treatment of diseases in humans.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.