Process for the synthesis of substituted alpha-aminoindan derivatives
US7456320B2 · kind B2 · utility
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Key dates
| Filing date | Feb 21, 2005 |
| Grant date | Nov 25, 2008 |
| Priority date | — |
| Expiry date | Feb 21, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the preparation of optically active substituted alpha-amino-indane derivatives of formula (I), which include: an asymmetric hydrogenation reaction of an en-amide derivative of formula (III) in presence of hydrogen and an optically active catalyst, in order to obtain an amide derivative of formula (II), a hydrolysis reaction of the amide derivative of formula (II) obtained in the previous step,in order to obtain optically active substituted alpha-amino-indane derivatives of formula (I).
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