Closed loop cardiac resynchronization therapy using cardiac activation sequence information

US7457664B2 · kind B2 · utility

Assignee

• Cardiac Pacemakers, Inc. · US

Inventors

• Yi Zhang · Mountain View, US
• Yinghong Yu · Shoreview, US
• Aaron R. McCabe · Edina, US
• Jiang Ding · Maplewood, US
• Jeffrey E. Stahmann · Ramsey, US
• Carlos Ricci · Apple Valley, US
• Scott A. Meyer · Rochester, US

Key dates

• Filing date: May 9, 2005
• Grant date: Nov 25, 2008
• Expiry date: Apr 6, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/365
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Cardiac monitoring and/or stimulation methods and systems that provide one or more of monitoring, diagnosing, defibrillation, and pacing. Cardiac signal separation is employed to detect, monitor, track, and/or trend closed-loop cardiac resynchronization therapy using cardiac activation sequence information. Devices and methods involve sensing a plurality of composite cardiac signals using a plurality of electrodes, the electrodes configured for implantation in a patient. A source separation is performed using the sensed plurality of composite cardiac signals, producing one or more cardiac signal vectors associated with all or a portion of one or more cardiac activation sequences. A cardiac resynchronization therapy is adjusted using one or both of the one or more cardiac signal vectors and the signals associated with the one or more cardiac signal vectors. In further embodiments, the cardiac resynchronization therapy may be initiated, terminated, or one or more parameters of the resynchronization therapy may be altered.