Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring
US7459145B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Oct 27, 2003 |
| Grant date | Dec 2, 2008 |
| Priority date | — |
| Expiry date | Jul 5, 2024 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/587
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides multifunctional magnetic nanoparticle probe compositions for molecular imaging and monitoring, comprising a nucleic acid or polypeptide probe, a delivery ligand, and a magnetic nanoparticle having a biocompatible coating thereon. The probe compositions may further comprise a fluorescent or luminescent resonance energy transfer moiety. Also provided are compositions comprising two or more such multifunctional magnetic nanoparticle probes for molecular imaging or monitoring. In particular, the nucleic acid or polypeptide probes bind to a target and generate an interaction observable with magnetic resonance imaging (MRI) or optical imaging. The invention thereby provides detectable signals for rapid, specific, and sensitive detection of nucleic acids, polypeptides, and interactions thereof in vivo.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.