Bone replacement material with orthophosphate

US7459170B2 · kind B2 · utility

Assignee

• BAM Bundesanstalt fuer Materialforschung und-pruefung · DE

Inventors

• Georg Berger · Panketal, DE
• Andrea Spitzer · Berlin, DE
• Christian Jäger · Berlin, DE
• Jutta Pauli · Berlin, DE
• Renate Gildenhaar · Berlin, DE

Key dates

• Filing date: Oct 20, 2003
• Grant date: Dec 2, 2008
• Expiry date: Apr 29, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C04B2235/80
• WIPO field: Materials, metallurgy
• WIPO sector: Chemistry

Abstract

The present invention relates to a material with orthophosphate and having a high solubility which can be used as a bioactive bone replacement material and as a substrate material in biotechnology. According to 31P-NMR measurements, the new material comprises Q0-groups of orthophosphate and Q1-groups of diphosphate, the orthophosphates or Q0-groups making up 65 to 99.9% by weight relative to the total phosphorus content of the finished material and the diphosphates or Q1-groups making up 0.1 to 35% by weight relative to the total phosphorus content of the finished material, and wherein according to X-ray diffractometric measurements and relative to the total weight of the finished material, 35 to 99.9% by weight of a main crystal phase consisting of Ca10Na(PO4)7, Ca10K(PO4)7, mixtures thereof or mixed crystals according to the general formula Ca10KxNa1−x(PO4)7, where x=0 to 1, is contained in the bone replacement material and 0.1 to 25% by weight of a substance selected from the group consisting of Na2CaP2O7, K2CaP2O7, Ca2P2O7 and mixtures thereof is contained as a secondary crystal phase, and the X-ray amorphous phases contained besides the main crystal phase jointly make up 0.1 t…