Recombinant gelatin-like proteins for use as plasma expanders
US7459431B2 · kind B2 · utility
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1References
20Claims
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Assignee
Inventors
Key dates
| Filing date | Mar 6, 2002 |
| Grant date | Dec 2, 2008 |
| Priority date | — |
| Expiry date | Mar 6, 2022 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P7/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to compositions suitable for plasma substitution comprising as a plasma expander a recombinant gelatin-like protein. Characteristic is that the gelatin-like protein essentially is free of hydroxyproline. This absence of hydroxyproline prevents the composition from gelling and thus allows the use of high-molecular weight proteins in order to establish a suitable colloid osmotic pressure. Specific advantage of the gelatin-like proteins is that these avoid the risk of anaphylactic shock that exists in conjunction with the use of commercially available preparations.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.