Quinoline and quinazoline derivatives having affinity for 5HT1-type receptors

US7459456B2 · kind B2 · utility

Assignee

• Glaxo Group Limited · GB

Inventors

• Matteo Biagetti · Verona, IT
• Alessandro Falchi · Sassari, IT
• Colin Philip Leslie · Verona, IT
• Giancarlo Merlo · Verona, IT
• Domenica Antonia Pizzi · Verona, IT
• Marilisa Rinaldi · Verona, IT
• Luigi Piero Stasi · Verona, IT
• Jessica Tibasco · Verona, IT

Key dates

• Filing date: Mar 16, 2007
• Grant date: Dec 2, 2008
• Expiry date: Mar 16, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C04B35/632
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of formula (I) and pharmaceutically acceptable salts thereof are provided:wherein R1, m, X, R2, n, W, p, Y, Z, R3, R4, R5 and q have the meanings as defined in the description. Methods of preparation and uses thereof in therapy, particularly for CNS disorders such as depression or anxiety, are also disclosed.