Manufacturing process for methyl phenidate and intermediates thereof

US7459467B2 · kind B2 · utility

Assignee

• IPCA LABORATORIES LIMITED · IN

Inventors

• Ashok Kumar · Jamkhed, IN
• Dharmendra Singh · Mumbai, IN
• Swapnali Hemant Patil · Jamkhed, IN
• Ganesh Devidas Mahale · Jamkhed, IN
• Uttamrao Sawant · Jamkhed, IN

Key dates

• Filing date: Jun 10, 2005
• Grant date: Dec 2, 2008
• Expiry date: May 15, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D211/34
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention discloses selective and complete reduction of pyridine ring in a biaryl system comprising ∝-substituted or non-substituted benzene ring and relates more specifically, not exclusively, for the manufacture of methylphenidate, which is used for treatment of Attention Deficit Hyperactive Disorder (ADHD) and also acts as central nervous system stimulant, by using palladium/C in a solvent such as C1-C4 alcohols in presence of molar quantities of organic and/or inorganic acids.