Method of forming a polymerized hemoglobin solution from stabilized hemoglobin
US7459535B2 · kind B2 · utility
2Cited by
28References
20Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 19, 2006 |
| Grant date | Dec 2, 2008 |
| Priority date | — |
| Expiry date | Oct 19, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/805
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A stabilized hemoglobin solution is contacted with polymerizing agent. The stabilized hemoglobin solution includes stabilized tetrameric hemoglobin. At least a portion of the stabilized tetrameric hemoglobin is polymerized by reaction with the polymerizing agent, thereby producing a polymerized hemoglobin solution. In one embodiment, the stabilized hemoglobin solution includes a filtrate formed by filtrating polymerized solution of native hemoglobin through a filter having a molecular weight cut off of about 100 kD.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.