N-TRADD active site and uses thereof
US7460961B2 · kind B2 · utility
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5References
47Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 20, 2004 |
| Grant date | Dec 2, 2008 |
| Priority date | — |
| Expiry date | Oct 4, 2025 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2500/04
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to the three dimensional solution structure of the N-terminal domain of TNFR-1 associated death domain protein (“N-TRADD”), as well as the identification and characterization of a C-TRAF2 binding active site of N-TRADD. Also provided for by the present invention are methods of utilizing the three dimensional structures for the design and selection of potent and selective inhibitors of TNF signaling pathways.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.