Device for the detection of at least one ligand contained in a sample that is to be analyzed

US7462326B2 · kind B2 · utility

Assignee

• Micronas GmbH · DE

Inventors

• Mirko Lehmann · Glückstadt, DE
• Claas Muller · Glückstadt, DE
• Holger Klapproth · Glückstadt, DE
• Ingo Freund · Endingen am Kaiserstuhl, DE

Key dates

• Filing date: Sep 26, 2003
• Grant date: Dec 9, 2008
• Expiry date: Sep 26, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N21/552
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Disclosed is a device for detecting at least one ligand contained in a sample that is to be analyzed. Said device comprises an optical waveguide, on the surface of which at least one ligand-specific receptor is directly or indirectly immobilized. The ligand bonds to said receptor during contact therewith. The inventive device comprises at least one optical source of radiation for injecting excitation radiation into the waveguide, the radiation being used for exciting emission of luminescence radiation in accordance with the bonding of the ligand to the receptor. At least one radiation receiver is integrated into the semiconductor substrate of a semiconductor chip so as to detect the luminescence radiation. The waveguide is integrated in a monolithic manner into the semiconductor substrate or is applied thereupon as a wave-guiding layer.