Compositions and methods for polynucleotide delivery
US7462592B2 · kind B2 · utility
8Cited by
7References
13Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 22, 2002 |
| Grant date | Dec 9, 2008 |
| Priority date | — |
| Expiry date | Feb 18, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2810/858
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates compositions and methods for increasing the uptake of polynucleotides into cells. Specifically, the invention relates to vectors, targeting ligands, and polycationic agents. The polycationic agents are capable of (1) increasing the frequency of uptake of polynucleotides into a cell, (2) condensing polynucleotides; and (3) inhibiting serum and/or nuclease degradation of polynucleotides.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.