Process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate and high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate

US7462718B2 · kind B2 · utility

Assignee

• SCHERING CORPORATION · US

Inventors

• Hilmar Weinmann · Glienecke, DE
• Matthias Schneider · Dossenheim, DE
• Michael Gottfried · Wuppertal, DE

Key dates

• Filing date: May 6, 2004
• Grant date: Dec 9, 2008
• Expiry date: Aug 10, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D215/20
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the production of high-purity rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]-piperazin-1-yl}-2,2-diphenylethan-1-one fumarate as well as rac-1-{4-[2-hydroxy-3-(5-quinolyloxy)propyl]piperazin-1-yl}-2,2-diphenylethan-1-one fumarate at a purity of at least 98.55% is described.