In situ or one-pot hydrogenation and reductive amination process
US7462742B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 23, 2007 |
| Grant date | Dec 9, 2008 |
| Priority date | — |
| Expiry date | Jan 23, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2601/14
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
An in situ or one-pot process for the preparation of the compounds of formula (I) uses a compound of general formula (I):and includes:a) the hydrogenation of a nitrile group of the compound of general formula (II):in which R1 to R4 are especially H or alkyl and n varies from 0 to 4, in the presence of a hydrogenation catalyst, a methylating agent and an organic acid as solvent, and at a temperature Ta below the initiation temperature of a reductive amination reaction, to give a primary amine from the nitrile group; andb) the reductive amination of the primary amine in the presence of hydrogen, at a temperature Tb above Ta, to give the dimethylated amine of general formula (I) by activation of the methylating age.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.