Hydroxyphenyl cross-linked macromolecular network and applications thereof

US7465766B2 · kind B2 · utility

Assignee

• The Cleveland Clinic Foundation · US

Inventors

• Anthony Calabro · Upper Darby, US
• Lee Akst · Boston, US
• Daniel Alam · Shaker Heights, US
• James Chan · San Francisco, US
• Aniq Darr · Lowerre, US
• Kiyotaka Fukamachi · Cleveland, US
• Richard A. Gross · Plainview, US
• David Haynes · Saint Peters, US
• Keiji Kamohara · Mayfield Heights, US
• Daniel P. Knott · Shaker Heights, US
• Hilel Lewis · Beachwood, US
• Alex Melamud · Durham, US
• Anthony Miniaci · Chagrin Falls, US
• Marshall Strome · Gates Mills, US

Key dates

• Filing date: Jul 7, 2005
• Grant date: Dec 16, 2008
• Expiry date: Aug 7, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/30
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A dihydroxyphenyl cross-linked macromolecular network is provided that is useful in artificial tissue and tissue engineering applications, particularly to provide a synthetic, implantable tissue matrix material for a wide variety of tissue types. In particular, artificial or synthetic cartilage, vocal cord material, vitreous material, soft tissue material and mitral valve material are described. In an embodiment, the network is composed of tyramine-substituted and cross-linked hyaluronan molecules, wherein cross-linking is achieved via peroxidase-mediated dityramine-linkages that can be performed in vivo. The dityramine bonds provide a stable, coherent hyaluronan-based hydrogel with desired physical properties.