Polyomavirus cellular epitopes and uses therefor
US7468186B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | Jul 24, 2006 |
| Grant date | Dec 23, 2008 |
| Priority date | — |
| Expiry date | Feb 4, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/708
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to HLA-A*02-restricted cellular epitopes within the VP1 polypeptide of a human polyomavirus, BK virus, which is associated with polyomavirus-associated nephropathy in kidney transplant patients. Preferred peptides correspond to amino acids residues 107-116, 108-116 and 44-52 of BKV VP1, and are processed in vivo in natural infection with BKV. Effector T cell populations stimulated by the peptides represent functional CTLs as assessed by cytotoxicity and cytokine production, and are reactive against cells presenting both the BKV peptides above and the JC virus homolog sequences.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.