Protein S functional assay
US7468257B2 · kind B2 · utility
1Cited by
47References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Dec 15, 2004 |
| Grant date | Dec 23, 2008 |
| Priority date | — |
| Expiry date | Apr 19, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/86
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The invention relates generally to a new functional protein S assay and kit that is based on the ability of endogenous protein S to prolong clotting time. In the assay procedure, a test plasma sample is diluted with protein S deficient plasma, followed by the addition of purified or recombinant tissue factor (pTF or rTF), purified natural or synthetic phospholipid (pPL or sPL) and activated protein C (APC) or protein C activator (PCA). The clotting time is then measured and compared to a standard curve or a normal control.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.