Method for producing amines from hydroxamic acids

US7468460B2 · kind B2 · utility

Assignee

• Archimica, Inc. · US

Inventors

• Andreas Meudt · Hofheim, DE
• Claudius Boehm · Frankfurt, DE

Key dates

• Filing date: Jul 5, 2006
• Grant date: Dec 23, 2008
• Expiry date: Jul 5, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C209/56
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A method for producing unprotected or carbamate-protected amines of formulae (II) and (III) or R1—NH2 (II) or R1—NHCO2R2 (III) by reacting hydroxamic acids of formula (I) (R1 CONHOH) with a) alkylpliosphonic acid anhydrite's, b) alcohol R2OH and c) optionally with a base, at a temperature ranging from 100 to +120°C., wherein the hydroxainic acid (I) is produced prior to or during reacting (in situ) and R1 is an optionally substituted linear or branched C1-C12 alkyl radical, substituted C3-C10 cycloalkyl, alkenyl, aryl or heteroaryl radical and R2 is an open-chain, cyclic or branched allyl, aryl or C1 to C12-alkyl radicals, or aryloxy, allyloxy or alkoxy radical possibly substituted with open-chain, cyclic or branched C1 to C12-alkyl radicals.