Adipose-derived stem cells and lattices

US7470537B2 · kind B2 · utility

Inventors

• Marc H. Hedrick · Encinitas, US
• Adam J. Katz · Charlottesville, US
• Ramon Llull · Palma, ES
• J. William Futrell · Pittsburgh, US
• Prosper Benhaim · Los Angeles, US
• Hermann Peter Lorenz · Stanford, US
• Min Zhu · Shanghai, CN

Key dates

• Filing date: Dec 17, 2003
• Grant date: Dec 30, 2008
• Expiry date: Jan 20, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/90
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides adipose-derived stem cells (ADSCs), adipose-derived stem cell-enriched fractions (ADSC-EF) and adipose-derived lattices, alone and combined with the ADSCs of the invention. In one aspect, the present invention provides an ADSC substantially free of adipocytes and red blood cells and clonal populations of connective tissue stem cells. The ADSCs can be employed, alone or within biologically-compatible compositions, to generate differentiated tissues and structures, both in vivo and in vitro. Additionally, the ADSCs can be expanded and cultured to produce molecules such as hormones, and to provide conditioned culture media for supporting the growth and expansion of other cell populations. In another aspect, the present invention provides an adipose-derived lattice substantially devoid of cells, which includes extracellular matrix material from adipose tissue. The lattice can be used as a substrate to facilitate the growth and differentiation of cells, whether in vivo or in vitro, into anlagen or even mature tissues or structures.