Method of inhibiting the expression and/or the activity of JNK
US7470686B2 · kind B2 · utility
0Cited by
2References
12Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jul 18, 2007 |
| Grant date | Dec 30, 2008 |
| Priority date | — |
| Expiry date | Jul 18, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D417/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is related to benzazole derivatives notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such benzazole derivatives. Said benzazole derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and/or 3. The present invention is furthermore related to novel benzazole derivatives as well as to methods of their preparation.X is O, S or NR0, with R0 being H or an unsubstantiated or substituted C1-C6 alkyl;G is an unsubstantiated or substituted pyrimidinyl group.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.