Benzimidazole quinolinones and uses thereof

US7470709B2 · kind B2 · utility

Assignee

• Novartis Vaccines and Diagnostics, Inc. · US

Inventors

• Paul A. Barsanti · Emeryville, US
• Dirksen Bussiere · Emeryville, US
• Stephen Harrison · Benicia, US
• Carla Heise · Benicia, US
• Johanna Jansen · San Francisco, US
• Elisa Jazan · Richmond, US
• Timothy Machajewski · Martinez, US
• Christopher McBride · Oakland, US
• William McCrea · Berkeley, US
• Simon Ng · Walnut Creek, US
• Zhi-Jie Ni · Emeryville, US
• Sabina Pecchi · Oakland, US
• Keith B. Pfister · Emeryville, US
• Savithri Ramurthy · Walnut Creek, US
• Paul A. Renhowe · Danville, US
• Cynthia Shafer · El Sobrante, US
• Joel B. Silver · Santa Cruz, US
• Allan S. Wagman · Belmont, US
• Marion Wiesmann · Emeryville, US
• Kelly Wayman · San Rafael, US

Key dates

• Filing date: Aug 19, 2003
• Grant date: Dec 30, 2008
• Expiry date: Sep 14, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of inhibiting various enzymes and treating various conditions are provided that include administering to a subject a compound of Structure I or IB, a pharmaceutically acceptable salt thereof, a tautomer thereof, or a pharmaceutically acceptable salt of the tautomer. Compounds having the Structure I and IB have the following structures and have the variables described herein. Such compounds may be used to prepare medicaments for use in inhibiting various enzymes and for use in treating conditions mediated by such enzymes.