N-aroyl cyclic amine derivatives as orexin receptor antagonists

US7470710B2 · kind B2 · utility

Assignee

• SmithKline Beeacham P.L.C. · GB

Inventors

• Clive Leslie Branch · Harlow, GB
• Wai Ngor Chan · Blieskastel, DE
• Amanda Johns · St Albans, GB
• Christopher Norbert Johnson · Saffron Walden, GB
• David John Nash · Little Walden, GB
• Riccardo Novelli · Harlow, GB
• Jean-Pierre Pilleux · Mayenne, FR
• Roderick Alan Porter · Ashwell, GB
• Rachel Elizabeth Anne Stead · Harlow, GB
• Geoffrey Stemp · Bishop's Stortford, GB

Key dates

• Filing date: Jun 25, 2002
• Grant date: Dec 30, 2008
• Expiry date: Apr 12, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D491/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to N-aroyl cyclic amine derivatives of formula (I), wherein X represents a bond, oxygen, NR3 or a group (CH2), wherein n represents 1, 2 or 3; Y represents CH2, CO, CH(OH), or CH2CH(OH); Het is an optionally substituted bicyclic heteroaryl group containing up to 4 heteroatoms selected from N, O and S; Ar2 represents an optionally substituted phenyl or a 5- or 6-membered heterocyclyl group containing up to 3 heteroatoms selected from N, O and S and their use as pharmaceuticals, specifically as orexin receptor antagonists.