Antitumor agents

US7470788B2 · kind B2 · utility

Assignee

• Wayne State University · US

Inventors

• Jerome P. Horwitz · Farmington Hills, US
• Lisa Polin · Oak Park, US
• Stuart T. Hazeldine · Taylor, US
• Thomas H. Corbett · Grosse Pointe Park, US

Key dates

• Filing date: Sep 9, 2005
• Grant date: Dec 30, 2008
• Expiry date: Mar 30, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of formula I:wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention also provides pharmaceutical compositions comprising a compound of formula I or a salt thereof, intermediates useful for preparing a compound of formula I, and therapeutic methods comprising administering a compound of formula I or a salt thereof to a mammal in need thereof.