Synthesis of 6,7-dihydro-5H-imidazo[1,2-a]imidazole-3-sulfonic acid amides

US7470795B2 · kind B2 · utility

Assignees

• Boehringer Ingelheim Pharmaceuticals, Inc. · US
• Boehringer Ingelheim International GmbH · DE

Inventors

• Xiao-Jun Wang · Danbury, US
• Thomas Wirth · Freinsheim, DE
• Thomas Nicola · Ingelheim am Rhein, DE
• Li Zhang · New Milford, US
• Rogelio P. Frutos · Sandy Hook, US
• Yibo Xu · Ridgefield, US
• Dhileepkumar Krishnamurthy · Westborough, US
• Laurence J. Nummy · Newburgh, US
• Richard J. Varsolona · Scotch Plains, US
• Chris Hugh Senanayake · Brookfield, US
• Jutta Kroeber · Bingen, DE
• Diana Reeves · New Milford, US

Key dates

• Filing date: Jul 25, 2005
• Grant date: Dec 30, 2008
• Expiry date: Jan 15, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D239/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed is a multi-step process for preparing a compound of Formula I:wherein R1 to R3 are as defined herein. The compounds of formula I inhibit the binding of human intercellular adhesion molecules to the Leukointegrins. As a result, these compounds are useful in the treatment of inflammatory and immune cell-mediated diseases.