Tramadol recovery process

US7470816B2 · kind B2 · utility

Assignee

• IPAC Laboratories Limited · IN

Inventors

• Ashok Kumar · Jamkhed, IN
• Suneel Yeshwant Dike · Jamkhed, IN
• Satish Rajanikant Soudagar · Mumbai, IN
• Chirag Hasmukh Shah · Jamkhed, IN
• Sandeep Madhavrao Burudkar · Jamkhed, IN
• Prashant Gautam · Jamkhed, IN
• Byju Nellithanath Thankachen · Jamkhed, IN
• Ashvini Saxena · Bengaluru, IN
• Manavalan Saravanan · Damoh, IN
• Gunjan Pramod Pathak · Damoh, IN
• Virendra Pal · Damoh, IN
• Rahul Karde · Damoh, IN
• Jaysingh Gehlot · Damoh, IN

Key dates

• Filing date: Nov 13, 2006
• Grant date: Dec 30, 2008
• Expiry date: Jan 1, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the resolution of isomeric tramadol mixtures comprising: providing a purification stock comprising both cis and trans tramadol; contacting the purification stock with an acid under conditions effective to form an acid salt of the cis and trans tramadol in the purification stock; and separating the cis tramadol acid salt from the trans tramadol to obtain a purified cis tramadol acid salt; and optionally converting the cis tramadol acid salt to cis tramadol or to a pharmaceutically active salt thereof.