Near infrared fluorescent contrast agent and method for fluorescence imaging

US7473415B2 · kind B2 · utility

Assignees

• FUJITSU LIMITED · JP
• SCHERING CORPORATION · US

Inventors

• Masayuki Kawakami · Yokohama, JP
• Hiroshi Kitaguchi · Tokyo, JP
• Kai Licha · Berlin, DE
• Christin Perlitz · Berlin, DE
• Hiroaki Eguchi · Kawanishi, JP
• Natsuko Tsuda · Nishinomiya, JP
• Kazuhiro Aikawa · Odawara, JP

Key dates

• Filing date: Mar 7, 2003
• Grant date: Jan 6, 2009
• Expiry date: Sep 14, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K49/0052
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A near infrared fluorescent contrast agent which is excellent in permeability in a living tissue and enables specific imaging of tumor and/or blood vessel, comprising a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R7, and R8 represent a C1-C10 alkyl group or the like; R3, R4, R5, R6, R9, R10, R11, and R12 represent a hydrogen atom, a C1-C6 alkyl group, an aryl group or the like; X1 and X2 represent a C1-C15 alkyl group or an aryl group and X1 and X2 in total have 0 to 4 carboxyl groups; m1, m2, and m3 represents 0 or 1; L1 to L7 independently represent a methine group; M represents a hydrogen atom, a metal, or a quaternary ammonium salt; and n represents an integer of 1 to 7 necessary for neutralizing charge.