Enzymatic production of glycolic acid
US7473545B2 · kind B2 · utility
15Cited by
17References
2Claims
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Key dates
| Filing date | Feb 28, 2007 |
| Grant date | Jan 6, 2009 |
| Priority date | — |
| Expiry date | Feb 28, 2027 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12P7/42
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Various methods are provided for the enzymatic production of glycolic acid from glycolonitrile. These methods include: 1) use of Acidovorax facilis 72W nitrilase mutants having improved nitrilase activity for converting glycolonitrile to glycolic acid, and 2) methods to improve catalyst stability and/or productivity. The methods to improve catalyst stability/productivity include use of reaction stabilizers, running the reactions under substantially oxygen free conditions, and controlling the concentration of substrate in the reaction mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.