Methods for the treatment of a traumatic central nervous system injury

US7473687B2 · kind B2 · utility

Assignee

• EMORY UNIVERSITY · US

Inventors

• Stuart W. Hoffman · Atlanta, US
• Arthur L. Kellermann · Atlanta, US
• Donald G. Stein · Atlanta, US
• David W. Wright · Atlanta, US
• Douglas W. Lowery-North · Atlanta, US

Key dates

• Filing date: Sep 27, 2006
• Grant date: Jan 6, 2009
• Expiry date: Sep 27, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of treating a subject with a traumatic central nervous system injury, more particularly, a traumatic brain injury, are provided. The methods comprise a therapy comprising a constant or a two-level dosing regime of progesterone. In one method, a subject in need thereof is administered at least one cycle of therapy, wherein the cycle of therapy comprises administering a therapeutically effective two-level intravenous dosing regime of progesterone. The two-level dosing regime comprises a first time period, wherein a higher hourly dose of progesterone is administered to the subject, followed by a second time period, wherein a lower hourly dose of progesterone is administered to the subject.