Proteins and polypeptides from coagulaslase-negative staphylococci

US7473762B2 · kind B2 · utility

Assignees

• THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN · IE
• THE TEXAS A&M UNIVERSITY SYSTEM · US

Inventors

• Timothy J. Foster · Dublin, IE
• Kirk McCrea · Houston, US
• Magnus Hook · Houston, US
• Stacy Davis · Houston, US
• Deirdre Nieidhin · Dublin, IE
• Orla Hartford · Duleek, IE

Key dates

• Filing date: Oct 21, 2003
• Grant date: Jan 6, 2009
• Expiry date: Jul 9, 2025

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/505
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Proteins and polypeptides from coagulase-negative staphylococcal bacteria such as S. epidermidis, including proteins designated SdrF, SdrG and SdrH, and their effective fragments such as their respective A domains, are provided which are useful in the prevention and treatment of infection caused by coagulase-negative staphylococcal bacteria such as S. epidermidis. The SdrF, SdrG and SdrH proteins are cell-wall associated proteins that specifically bind host proteins and which each have a highly conserved motif of which the consensus sequence is TYTFTDYVD (SEQ ID NO: 16). The proteins and polypetides may be useful in generating antibodies for the diagnosis and treatment of coagulase-negative staphylococcal infections.